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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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JEOL jem 1200 ex ii transmission electron microscopes tem
Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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JEOL millisecond heating rates
Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
Transmission Electron Microscopy, supplied by JEOL, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron <t>microscope</t> observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.
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Image Search Results


Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron microscope observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Article Title: Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol.

doi: 10.1016/j.biopha.2022.113402

Figure Lengend Snippet: Fig. 6. Effect of fucoidan on ferroptosis of hepatocytes. Electron microscope observation of liver tissues exhibited ferroptosis changes induced by alcohol exposure (A). Western blotting data showed that high-dose fucoidan treatment activated the p62/Keap1/Nrf2 pathway and promoted the expressions of SLC7A11 and GPX4 compared to the model group (B). n = 3/group. White arrow, mitochondrial membrane; black arrow, and the mitochondrial cristae. * , Compared with the control group, P < 0.05; * *, Compared with the control group, P < 0.01; #, Compared with the model group, P < 0.05; ##, Compared with the model group, P < 0.01.

Article Snippet: The ultrastructure changes were examined by a transmission electron microscope (JEOL JEM-1200, Tokyo, Japan) equipped with a Gatan Orius 830 camera.

Techniques: Microscopy, Western Blot, Membrane, Control